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TRV130 hydrochloride

CAS號	1401031-39-7
規格	2mg5mg	純度	98%
貨號	HY-16655A	貨期	3天
品牌	Medchemexpress	庫存	需咨詢
規格	2mg5mg
純度	98%
貨號	HY-16655A
貨期	3天
品牌	Medchemexpress
庫存	---
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參考價：￥1650.00 元/2mg

立即詢盤

貨號	品牌	純度	規格	參考價	貨期
HY-16655A	Medchemexpress	98%	2mg5mg	￥1650.00元/2mg	3天

產品詳情

詳細信息(中文)：
TRV 130鹽酸鹽是_mu_-opioid受體新型配體，能誘導強G蛋白信號，pEC50值為8.1，與嗎啡活性相當，但對_beta_-arrestin招募活性弱。

詳細信息(英文)：
產品描述：TRV130 (hydrochloride)TRV 130 Hcl is a novel μ-opioid receptor (MOR) G protein-biased ligand; elicits robust G protein signaling(pEC50=8.1), with potency and efficacy similar to morphine, but with far less β-arrestin recruitment and receptor internalization._x000D_ IC50 value: 8.1 (pEC50. G protein assay) [3]_x000D_ Target: MOR ligand_x000D_ in vitro: In cell-based assays, TRV130 elicits robust G protein signaling, with potency and efficacy similar to morphine, but with far less β-arrestin recruitment and receptor internalization [1]._x000D_ in vivo: In mice and rats, TRV130 is potently analgesic while causing less gastrointestinal dysfunction and respiratory suppression than morphine at equianalgesic doses [1]. Compared to morphine, TRV130 (3, 4.5mg) elicited higher peak analgesia (105, 116 seconds latency vs 75 seconds for morphine, P

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物理化學性質
英文名	6-Oxaspiro[4.5]decane-9-ethanamine, N-[(3-methoxy-2-thienyl)methyl]-9-(2-pyridinyl)-, hydrochloride (1:1), (9R)-
中文名	TRV130 hydrochloride
CAS號	1401031-39-7	溶解性	---
分子量	423.02025	熔點	---
密度	---	沸點	---